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Functional characteristics of a calcium-dependent protein kinase (MaCDPK1) enduring stress tolerance from Morus atropurpurea Roxb.
Calcium-dependent protein kinases Mulberry Salt stress Drought stress ABA
2024/1/19
Calcium-dependent protein kinases (CDPKs), as an important calcium sensor in plants, are widely involved in the signal transmission process of growth and development, pathogen defense response and bio...
Hydrogen Sulfide-linked Persulfidation of ABSCISIC INSENSITIVE 4 Controls Arabidopsis ABA Responses Through the Transactivation of Mitogen-Activated Protein Kinase Kinase Kinase 18
Hydrogen sulfide Persulfidation DES1 59 ABI4 MAPKKK18 transactivation ABA response
2023/12/8
Hydrogen sulfide (H2S) is a signaling molecule that regulates plant hormone and stress responses. The phytohormone abscisic acid (ABA) plays important role during plant adaptation to unfavorable envir...
Chemical control of receptor kinase signaling by rapamycin-induced dimerization
leucine-rich repeat receptor kinase brassinosteroids BRI1 BAK1 FLS2
2023/12/7
Membrane-localized leucine-rich repeat receptor kinases (LRR-RKs) sense diverse extracellular signals, and coordinate and specify cellular functions in plants. However, functional understanding and id...
Protein kinase sensors: an overview of new designs for visualizing kinase dynamics in single plant cells
plant cells protein kinase sensors kinase dynamics signaling networks SnRK2
2023/12/1
Protein kinase dynamics play key roles in regulation of cell differentiation, growth, development and in diverse cell signaling networks. Protein kinase sensors enable visualization of protein kinase ...
Lysine biofortification in rice by modulating feedback inhibition of aspartate kinase and dihydrodipicolinate synthase
rice Lysine aspartate kinase dihydrodipicolinate synthase
2023/7/20
Lysine is the main limiting essential amino acid (EAA) in the rice seeds, which is a major energy and nutrition source for humans and livestock. In higher plants, the rate-limiting steps in lysine bio...
Identification of the Arabidopsis calmodulin-dependent NAD+ kinase that sustains the elicitor-induced oxidative burst
NAD+kinase Calmodulin Calcium NADP+42 zeta toxin flagellin22 Arabidopsis thaliana
2024/2/27
NADP(H) is an essential cofactor of multiple metabolic processes in all living organisms, and in plants, NADP(H) is required as the substrate of Ca2+-dependent NADPH oxidases, which catalyze a reactiv...
Enhanced tolerance to low-K+ stress in tobacco plants, that ectopically express the CBL-interacting protein kinase CIPK23 gene
low-K+ tolerance potassium tobacco
2016/7/6
Tobacco (Nicotiana tabacum) has a relatively high requirement for potassium (K+). However, the molecular basis of tolerance to low-K+ stresses in tobacco still remains unknown. Here, we report the rol...
A conserved water-mediated hydrogen bond network defines bosutinib’s kinase selectivity
Humans Water Quinolines Nitriles Aniline Compounds src-Family Kinases Amino Acid Substitution Conserved Sequence Substrate Specificity Hydrogen Bonding
2016/5/25
Kinase inhibitors are important cancer drugs, but they tend to display limited target specificity, and their target profiles are often challenging to rationalize in terms of molecular mechanism. Here ...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway
Transepithelial Electrical Resistance Phosphatidylinositol 3-Kinase-Akt-mTOR Signaling Pathway
2016/5/20
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of...
The Effects of Pre-slaughter Stress and Season on the Activity of Plasma Creatine Kinase and Mutton Quality from Different Sheep Breeds Slaughtered at a Smallholder Abattoir
Abattoir Enzymes Color Meat pH Temperature Tenderness
2016/5/16
The objective of the current study was to determine the effect of pre-slaughter stress, season and breed on the activity of plasma creatine kinase (CK) and the quality of mutton. One hundred and seven...
Decreased Activity in Neuropathic Pain Form and Gene Expression of Cyclin-Dependent Kinase5 and Glycogen Synthase Kinase-3 Beta in Soleus Muscle of Wistar Male Rats
Neuropathic Pain Soleus Muscle CDK5 Protein Kinase
2015/11/6
Background: The relationship between decreased activity/neuropathic pain and gene expression alterations in soleus muscle has remained elusive.
Efflux of Creatine Kinase from Isolated Soleus Muscle Depends on Age, Sex and Type of Exercise in Mice
Skeletal muscle eccentric contractions muscle damage CK activity
2015/8/28
Elevated plasma creatine kinase (CK) activity is often used as an
indicator of exercise-induced muscle damage. Our aim was to
study effects of contraction type, sex and age on CK efflux from
iso...
Soy protein ingestion results in less prolonged p70S6 kinase phosphorylation compared to whey protein after resistance exercise in older men
Anabolic signalling Supplementation Aging
2015/7/30
The phosphorylation of p70S6 Kinase (p70S6K) is an important step in the initiation of protein translation. p70S6K phosphorylation is enhanced with graded intakes of whey protein after resistance exer...
Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
MAPK DNA fragmentation apoptosis Bax
2015/6/24
Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphas...