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MACdb数据库系统建立了癌症-代谢物关联关系的收集标准，通过使用一系列本体体系（Ontology）对癌症类型、特征、代谢物标准化，构建了高一致性的综合知识集合。当前版本的知识库共收录了462篇文献，提取了40,710个癌症-代谢物关联关系对，共涉及到269个癌症特征，涵盖17类高发病率或高死亡率癌症类型，是当前涵盖癌症类型最全的癌症-代谢物关联知识库。MACdb构建了便捷高效的检索和过滤系统，支...
石河子大学医学院代谢性疾病研究团队在《Cancer Science》发表阐明肥胖诱发前列腺骨转移的可能机制的研究论文（图）
石河子大学医学院 代谢性疾病 Cancer Science 肥胖诱发 前列腺骨 转移 可能机制 研究论文
2020/10/28
近日，我院代谢性疾病研究团队在日本肿瘤联合会官方期刊《Cancer Science》，以长文形式发表了题为《Caprylic acid(C8:0) promotes bone metastasis of prostate cancer by dysregulated adipo-osteogenic balance in bone marrow》（2020 Aug 8;111(10):3600-1...
Nutritional metabolomics and breast cancer risk in a prospective study
breast cancer diet nutrition metabolomics biomarker tocopherol alcohol androgen fat
2018/11/15
Background: The epidemiologic evidence for associations between dietary factors and breast cancer is weak and etiologic mechanisms are often unclear. Exploring the role of dietary biomarkers with meta...
Whole-grain intake and total, cardiovascular, and cancer mortality: a systematic review and meta-analysis of prospective studies
whole grain cardiovascular disease cancer mortality meta-analysis
2018/12/3
Background: The potential role of whole grain in preventing various mortality outcomes has been inconsistently reported in a wealth of prospective observational studies.
Lipid biomarkers and long-term risk of cancer in the Women’s Health Study
cancer lipids metabolomics triglycerides women
2018/11/30
Background: Lipid biomarkers, such as HDL-cholesterol concentrations, have been shown to have positive, inverse, and null associations with total, breast, and colorectal cancer risks. Studies of novel...
Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
breast cancer EPIC antioxidants carotenoids plasma
2018/11/27
Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity.
Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)
cohort study epidemiology obesity physical activity exercise mortality population attributable fraction
2018/12/24
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity c...