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Theory of single-molecule experiments in the overstretching force regime
Theory of single-molecule experiments the overstretching force regime Biological Physics
2012/6/5
We present a statistical mechanics analysis of the finite-size elasticity of biopolymers, consisting of domains which can exhibit transitions between more than one stable state at large applied force....
Stochastic emergence of multiple intermediates detected by single-molecule quasi-static mechanical unfolding of protein
single-molecule detection protein folding molecular force microscopy molecular dynamics energy landscape
2010/12/2
Experimental probing of a protein-folding energy landscape can be challenging, and energy landscapes comprising multiple intermediates have not yet been defined. Here, we quasi-statically unfolded sin...