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Characterisation of CASPR2 deficiency disorder-a syndrome involving autism,epilepsy and language impairment
CNTNAP2 Epilepsy Intellectual disability Language regression Autism
2016/5/3
Background: Heterozygous mutations in CNTNAP2 have been identified in patients with a range of complex phenotypes including intellectual disability, autism and schizophrenia. However heterozygous CNTN...
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
Genetic risk autism spectrum disorders neuropsychiatric variation general population
2016/5/3
Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of that risk are unclear in people not ascertained for neuropsychiatric sym...
Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder
constitutional Pten dysfunction mice
2015/12/21
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, genetic component. Germline
mutations in the tumor suppressor Pten are a well-established risk factor...
Emotional language processing in autism spectrum disorders: a systematic review
autism spectrum disorders asperger syndrome
2015/12/18
In his first description of Autism Spectrum Disorders (ASD), Kanner emphasized emotional
impairments by characterizing children with ASD as indifferent to other people, selfabsorbed, emotionall...
A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment
autism intellectual disability
2015/12/18
FOXP1 (forkhead box protein P1; OMIM 605515) belongs to the FOX
gene family of transcription factor proteins, defined by the presence of
a characteristic DNA-binding domain known as the forkhe...
The Basis of Hyperspecificity in Autism:A Preliminary Suggestion Based on Properties of Neural Nets
Hyperspecificity in Autism Preliminary Suggestion Neural Nets
2015/6/19
This article reviews a few key ideas about the representation of information of information in neural networks, and uses these ideas to address one aspect of autism, namely the apparent hyperspecifici...
Emotional language processing in autism spectrum disorders: a systematic review
autism spectrum disorders asperger syndrome social emotion affect language
2015/5/13
In his first description of Autism Spectrum Disorders (ASD), Kanner emphasized emotional impairments by characterizing children with ASD as indifferent to other people, selfabsorbed, emotionally cold,...
Processing of Emotion Words by Patients with Autism Spectrum Disorders: Evidence from Reaction Times and EEG
Autism spectrum disorders EEG ERP Emotion words LPC Lexical decision task
2015/5/5
This study investigated processing of emotion words in autism spectrum disorders (ASD) using reaction times and event-related potentials (ERP). Adults with (n = 21) and without (n = 20) ASD performed ...
A Perceptual–Motor Deficit Predicts Social and Communicative Impairments in Individuals With Autism Spectrum Disorders
autism spectrum disorders social deficits perception perceptual–motor integration action capability estimation affordance perception
2015/4/21
Individuals with autism spectrum disorders (ASDs) have known impairments in social and motor skills. Identifying putative underlying mechanisms of these impairments could lead to improved understandin...
Exceptions and anomalies: An ERP study on context sensitivity in autism
Autism Asperger syndrome Context Linguistic processing Reasoning ERPs N400 effect Late positive component Sustained negativity
2015/4/8
Several studies have demonstrated that people with ASD and intact language skills still have problems processing linguistic information in context. Given this evidence for reduced sensitivity to lingu...
Defeasible reasoning in high-functioning adults with autism: Evidence for impaired exception-handling
Autism Adults High-functioning Reasoning Exceptions Context Mental flexibility
2015/4/7
While autism is one of the most intensively researched psychiatric disorders, little is known about reasoning skills of people with autism. The focus of this study was on defeasible inferences, that i...
Pragmatic Inferences in High-Functioning Adults with Autism and Asperger Syndrome
Autistic disorder Asperger syndrome Pragmatics Inferences Scalar implicatures Language understanding
2015/4/7
Although people with autism spectrum disorders (ASD) often have severe problems with pragmatic aspects of language, little is known about their pragmatic reasoning. We carried out a behavioral study o...