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Evolution of language: Lessons from the genome
Genetics and genomics Speech and language Evolution
2017/8/28
The post-genomic era is an exciting time for researchers interested in the biology of speech and language. Substantive advances in molecular methodologies have opened up entire vistas of investigation...
Investigation of the biological basis of human speech and language is being transformed by developments in molecular technologies, including high-throughput genotyping and next-generation sequencing o...
Genome-wide analysis identifies a role for common copy number variants in specific language impairment
Genome-wide analysis copy number variants specific language impairment
2015/5/13
An exploratory genome-wide copy number variant (CNV) study was performed in 127 independent cases with specific language impairment (SLI), their first-degree relatives (385 individuals) and 269 popula...
Genome wide identification of Fruitless targets suggests a role in upregulating genes important for neural circuit formation
Genome wide identification upregulating genes neural circuit
2015/5/6
The fruitless gene (fru) encodes a set of transcription factors (Fru) that display sexually dimorphic gene expression in the brain of the fruit-fly; Drosophila melanogaster. Behavioural studies have d...
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
ALSPAC GWAS imprinting neurodevelopmental disorder specific language impairment
2015/5/5
Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of ...
Genome-wide screening for DNA variants associated with reading and language traits
pleiotropic variants CLDRC developmental dyslexia GWAS language meta-analysis reading reading disability SLIC specific language impairment
2015/5/5
Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performe...
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl’s gyrus
Auditory network genetics genome-wide association scan Heschl’s gyrus language network magnetic resonance imaging speech processing surface-based
2015/5/5
Heschl’s gyrus (HG) is a core region of the auditory cortex whose morphology is highly variable across individuals.This variability has been linked to sound perception ability in both speech and music...
A Genome Wide Association Study of Mathematical Ability Reveals an Association at Chromosome 3q29, a Locus Associated with Autism and Learning Difficulties:A Preliminary Study
Genome Wide Mathematical Ability Chromosome 3q29 Locus Associated with Autism Learning Difficulties
2015/5/5
Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability...
Consanguinity studies and genome research in Mediterranean developing countries
autosomal recessive disorders exome homozygosity genomics of consanguinity homozygosity index
2015/4/21
Classical studies of consanguinity have taken advantage of the relationship between the gene frequency for a rare autosomal recessive disorder (q) and the proportion of offspring of consanguineous cou...