搜索结果: 1-7 共查到“理学 TRiC”相关记录7条 . 查询时间(0.046 秒)
2023年3月15日，国际学术期刊Science Advances在线发表了中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）丛尧研究组题为 “Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT” 的研究论文。研究人员应用冷冻电镜结合交联质谱技术，捕获了辅伴侣plp2协同TRiC在ATP...
钙离子作为第二信使，在细胞生命活动中发挥重要作用。肌浆网/内质网膜上RyR受体和IP3R是钙离子释放的重要通道，而SERCA蛋白是钙库吸收钙离子的重要离子泵。这些蛋白质机器的顺利发挥功能有赖于一系列离子通道的共同参与和协同完成。新型离子通道TRIC在钙离子释放过程中提供反向离子电流，帮助钙离子顺利转运。中国科学院遗传与发育生物学研究所陈宇航研究组开展了生物信息学分析，发现TRIC家族存在于高等生物...
近日，中国科学院生物化学与细胞生物学研究所丛尧研究组的最新研究成果，以Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT为题，在线发表在Scient...
TRIC离子通道在人体中发挥了重要的生理功能，其缺失或突变也和一些疾病密切相关。TRIC离子通道具有TRIC-A和TRIC-B两种亚型。TRIC-A通道是治疗恶性高血压潜在的药物靶点；TRIC-B通道与骨发育不全相关。因此TRIC离子通道的三维结构-功能研究将对理解心肌细胞和骨骼肌细胞等组织中的钙离子信号具有重要意义。生物信息学研究发现TRIC离子通道不仅存在于哺乳动物中，而且在原核生物中也存在同...
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement
4.0-A resolution cryo-EM structure mammalian chaperonin TRiC/CCT reveals unique subunit arrangement
2015/12/11
The essential double-ring eukaryotic chaperonin TRiC/CCT (TCP1-ring complex or chaperonin containing TCP1) assists the folding of approximately 5-10% of the cellular proteome. Many TRiC substrates can...
TRiC's tricks inhibit huntingtin aggregation
Amyloid Cryo electron microscopy (cryoEM) Cryo electron tomography (cryoET)
2015/12/11
In Huntington's disease, a mutated version of the huntingtin protein leads to cell death. Mutant huntingtin is known to aggregate, a process that can be inhibited by the eukaryotic chaperonin TRiC (TC...
A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1
Direct Regulatory Interaction TRiC Stress-Responsive Transcription Factor HSF1
2015/12/11
Heat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by which cytosolic...